The usual suggested Omega-3 intake is 1 – 4 grams per day. There is a suggestion in “The Queen of Fats” by Susan Allport that 10 grams per day would be helpful after a heart attack for prevention of future problems. However, there is little research available concerning the effects of higher doses. A search for “high intake EPA” did return an interesting article entitled “Ultra-High Fish Oil Intake of Yup’ik Eskimos Linked to Better Health” which may provide support for ultra high Omega-3 supplementation.
While the actual intake of Omega-3 was not measured, the study suggests that the Eskimo population intake was more than “20 times” that of the average Western diet due to the traditional fish diet. Higher levels of EPA and DHA measured in blood tests were linked to a decreased level of C-reactive protein (CRP) which is a known inflammatory biomarker linked to coronary artery disease. The researchers also found the Yup’ik with higher levels of EPA and DHA had lower triglycerides and higher HDL cholesterol (good cholesterol).
With regard to the actual blood test results, the association between EPA and DHA and (reduced) CRP was stronger when EPA was at a concentration of equal to or more than 3 percent of total fatty acids in the blood samples, and DHA at concentrations of equal to or more than 7 percent of total fatty acids in the blood samples. The study’s researchers wrote in conclusion, “the high consumption of EPA and DHA by Yup’ik Eskimos may partially explain the relatively low prevalence of CVD [cardiovascular disease] and diabetes in this population. [http://www.isagenixhealth.net/2010/03/ultra-high-fish-oil-intake-of-yupik-eskimos-linked-to-better-health/]
I do not have easy access to Omega-3 blood level tests, so I cannot check my blood levels of EPA and DHA. However, I have seen a significant decrease in triglycerides and blood pressure since I started taking lower doses of fish oil. Based on this study, I have started taking 3 tablespoons of High EPA fish oil, morning and evening, for a total intake of about 60 g per day.
- Diabetes: The Omega-3 Files Revisited (diabetesdialectics.wordpress.com)